The proteome and metabolome carry the fingerprint too — on the right scale
Loading the numbers from site/data/multiomic.json…
How it was done
The 20-protein panel that was sent to the human atlas
1. Same proteins, two scales
The proteomics problem in one picture
Show R² by component
2. The protein ladder beside the RNA ladder
Per human tissue, 20-protein panel
3. Recalibration: coverage and set size, side by side
4. Fusion under the species shift
5. The design that is not nested
6. RNA markers at the protein level
7. Metabolites: two mouse atlases, and exercise
Mouse aging atlas, 20-metabolite panel, per organ
Where the numbers come from
Data sources
- MoTrPAC reporter-ion files. MoTrPAC Study Group, rat 6-month endurance-training study (pass1b-06), untargeted proteomics, peptide-level reporter-ion intensities and vial metadata from the Data Hub quant-id folders
rat-training-06/<release>/proteomics-untargeted/<tissue>/prot-pr/(filesmotrpac_pass1b-06_<tissue>_prot-pr_rii-results.txtand_vial-metadata.txt;_v2.0suffix in c2.0), releases c1.0 (rn6, the main analysis) and c2.0 (rn7, the robustness run). motrpac-data.org; MoTrPAC Study Group, Nature 629:174–183 (2024). Used under the consortium's data-use terms. - Human TMT proteome of GTEx tissues. Jiang L, Wang M, Lin S, et al. A quantitative proteome map of the human body. Cell 183:269–283.e19 (2020). doi:10.1016/j.cell.2020.08.036; PRIDE PXD016999. Supplementary tables S1–S7 (mmc2–mmc8) from the journal site.
- Human label-free tissue atlas. Wang D, Eraslan B, Wieland T, et al. A deep proteome and transcriptome abundance atlas of 29 healthy human tissues. Mol Syst Biol 15:e8503 (2019). doi:10.15252/msb.20188503; PRIDE PXD010154. Tables EV1–EV8 from Europe PMC (PMC6379049).
- Mouse SILAC tissue proteome. Geiger T, Velic A, Macek B, et al. Initial quantitative proteomic map of 28 mouse tissues using the SILAC mouse. Mol Cell Proteomics 12:1709–1722 (2013). doi:10.1074/mcp.M112.024919. Supplementary table S1 (mmc1).
- Mouse exercise metabolome. Sato S, Dyar KA, Treebak JT, et al. Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis. Cell Metab 34:329–345.e8 (2022). doi:10.1016/j.cmet.2021.12.016. Supplementary tables (mmc2–mmc8).
- Mouse aging metabolome. A metabolic atlas of mouse aging. Metabolomics Workbench study ST003188 (analysis AN005236), project PR001984, Mullen Lab, Keck School of Medicine, University of Southern California; released 2025-11-18. doi:10.21228/M88J0W. CC BY 4.0. Metabolomics Workbench is supported by NIH grant U2C-DK119886.
Download URLs and sha256 of every external file: results_multiomic/02_discovery/download_log.csv and the data table of docs/REPRODUCIBILITY.md; third-party data committed here and their licences: NOTICE.md.